You can exclude folders and files from your backup or sync from the Exclusions tab under Settings. Note that exclusions apply to your backups and syncs, as well as ongoing transfers in Uploads. They need to be added before setting up your backup/sync.
You'll see a list of the folders and files excluded by default. They cannot be deleted but additional ones can be added.
To exclude a folder:
To exclude files: Enter the file extensions in the field, separated by a comma.